A DEGRONIMID™ is a small molecule that combines the ability to recruit a target protein of interest and the ubiquitination machinery.
Proteasomes are protein complexes inside all eukaryotes and archaea, and in some bacteria. The main function of the proteasome is to degrade unneeded or damaged proteins by proteolysis, a chemical reaction that breaks peptide bonds.
Ubiquitin is a small protein that is found in almost all cells. It plays a central part in controlling the degradation and localization of proteins in the body.
Targeted Protein Degradation
The ubiquitin-proteasome pathways play a major role in cellular protein destruction, and regulates the fundamental cellular processes, such as cell cycle, cell signalling, and development.