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C4 Therapeutics is seeking a highly talented and experienced project manager to contribute to the development of novel degrader therapeutics by maximizing our external research capabilities. The ideal candidate will have the scientific background and industry experience to accelerate the C4T portfolio projects towards goals by managing the planning, execution, and delivery of external research with contract research organizations (CROs) while adhering to a budget, scope and timeline requirements.  The Project Manager of External Research will have the opportunity to play a key role in the fulfillment of the company’s strategic, scientific and cultural vision. Key ResponsibilitiesAs Project Manager for External…

C4 Therapeutics, Inc. is seeking a highly motivated DMPK Scientist to contribute to the discovery and development of small molecule therapeutics that enable the UPS-mediated degradation of proteins implicated in disease. Reporting to the Senior Director of DMPK, the ideal DMPK candidate will be responsible for internal and external DMPK data generation, problem-solving, and ongoing nimble integration of DMPK discipline into C4T’s advancing portfolio.  Objectives:Broad understanding of DMPK function in drug discovery and developmentSupport C4T drug discovery projects ranging from lead optimization to candidate selection through generation, analysis and interpretation of internally and externally generated ADME dataDesign and execution of in…

We are seeking an enthusiastic, scientifically motivated in vivo pharmacologist to be a key member of our team developing a new class of targeted protein degradation therapeutics.  In this role, you will apply your in vivo pharmacology expertise and leadership capabilities to support multiple oncology programs.  Key ResponsibilitiesImmediately as In Vivo Pharmacology Lead, you will help develop the in vivo strategy alone or in partnership with a senior scientist depending on your experience level.  You will communicate plans and timelines across functions, and oversee the execution of studies (including tolerability, PD, efficacy) through an external CRO. Thus, this role will…

We are seeking an enthusiastic, scientifically motivated research scientist to join our Biochemistry, Biophysics & Crystallography team. The candidate will play a significant role in the structure-guided design of hetero-bifunctional degraders to advance early drug discovery projects and in doing so will be participating in laying the design foundations for an emerging new drug modality with the potential to address yet to be drugged targets.  The ideal candidate will possess a strong background in the fields of structural biology or biophysics and a foundation in small molecule drug discovery.  In addition, the successful candidate will have a strong commitment to…

C4 Therapeutics is pioneering a new class of drugs. Our technology platform produces small molecule drugs that harness machinery already present in cells to selectively target disease-relevant proteins for degradation. Our approach has the potential to address a broad range of diseases including cancer, infectious disease, and autoimmune disorders. ResponsibilitiesPrepare and negotiate contractsAnalyze the terms and conditions of both new and existing contracts, including but not limited to: CRO master service agreements, vendor agreements, statements of work/work orders, consulting agreements, clinical supply manufacturing agreements, confidential disclosure agreements, sponsored research agreements, and material transfer agreements.Liaise with the accounting department on business financial…

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