Defining “Undruggable” with Stew Fisher, CSO

Think about the most important scientific advancements that have shaped drug discovery over the last few decades, and then consider this daunting and humbling statistic: A relatively small percentage of the proteins that drive disease—only about 15%—are within the reach of drug hunters today.

The other roughly 85% are considered “undruggable.” But what does that really mean?

In this installation of Deggie’s Room, hear from Stew Fisher, Ph.D., our chief scientific officer, as he dives into undruggables. In this brief clip, Stew shares how targeted protein degradation offers new avenues to expand the universe of proteins that we can successfully target with medicines that meaningfully improve patients’ lives.